Features of the local cytokine profile of patients with bullous keratopathy by using personalized therapy with cellular technologies

Background . Today we have active development of ophthalmic surgery, but the role cytokines in pathogenesis bullous keratopathy cornea remains insufficiently studied at present. The aim To study dynamics local cytokine profile by using personalized treatment with suspension autologous blood mononuclears. Material and methods Two groups patients were formed: main group (30 people, 30 eyes), who received an intrastromal injection a mononuclears comparison (28 28 course pharmacotherapy. level interleukins (IL) – IL-10, IL-4, IL-6, IL-1ß, transforming growth factor beta-2 (TGF-β2), tumor necrosis alpha (TNF-α) was determined lacrimal fluid patient’s eye enzyme immunoassay. Results All before showed increase IL-1ß 3.3 times, IL-6 4.2 TNF-α 2.0 times (p < 0.05); IL-10 TGF-β2 1.1 > ˂ 0.05). In group, after treatment, there decrease 2.1 1.8 1.5 IL-4 1.9 1.4 0.05), persisting for 12 months. There short-term 1.7 1.2 >< 0.05) which then reached initial values. Conclusion. is imbalance system pro- anti-inflammatory fluid. Injection mononuclear cells stroma reduces severity compared to Key words: keratopathy, cellular technologies, leukocytes, cytokines>˂ Conclusion